解析に用いた抗がん剤(薬剤)の入手先、溶媒、標的分子、用いた処理濃度等のリスト

Chem_id Compound Cell Manufacturer Solvent Target/mode of action Concentration for treatment
C001 2-Deoxyglucose HT29 Sigma distilled water glycolysis 10mM
C002 Tunicamycin HT29 Nacalai Tesque (Kyoto, Japan) DMSO N-glycosylation 3μg/ml
C003 Thapsigargin HT29 Wako Pure Chemical Industries DMSO SERCA 10nM
C004 A23187 HT29 Wako Pure Chemical Industries DMSO Ca2+ ionophore 3μM
C005 Cisplatin HT29 Bristol-Myers Squibb DMSO DNA cross-linker 30μM
C006 Trichostatin A HT29 Wako Pure Chemical Industries DMSO HDAC 300nM
C007 Vorinostat HT29 Cayman Chemical Company (Ann Arbor, MI, US) DMSO HDAC 10μM
C008 Bortezomib HT29 Millennium Pharmaceuticals Inc (Cambridge, MA, US) DMSO proteasome 100nM
C009 MG-132 HT29 Peptide Institute (Osaka, Japan) DMSO proteasome 1μM
C010 Geldanamycin HT29 Sigma DMSO Hsp90 30nM
C011 17-AAG HT29 Wako Pure Chemical Industries DMSO Hsp90 100nM
C012 Vincristine HT29 Eli Lilly (Indianapolis, IN, US) distilled water tubulin 30nM
C013 Paclitaxel HT29 Bristo-Myers Squibb (New York, NY, US) DMSO tubulin 30nM
C014 Docetaxel HT29 Astra Zeneca, Inc (London, UK) DMSO tubulin 30nM
C015 5-FU HT29 Sigma DMSO Pyrimidine 100μM
C016 Gemicitabine HT29 Eli Lilly Saline Pyrimidine 1μM
C017 Melphalan HT29 Sigma 75%DMSO DNA cross-linker 100μM
C018 Mitomycin C HT29 Sigma 50%DMSO DNA alkylator 10μM
C019 Oxaliplatin HT29 Yakult Co.Ltd., DMSO DNA cross-linker 3μM
C020 Bleomycin HT29 Sigma distilled water DNA cleavage? 30μg/ml
C021 Actinomycin D HT29 Sigma DMSO DNA replication/RNA synthesis 30nM
C022 Neocarzinostatin HT29 Sigma - DNA cleavage? 3μg/ml
C023 Methotrexate HT29 Sigma DMSO DHFR 1μM
C024 6-Mercaptopurine HT29 Sigma DMSO Purine 100μM
C025 Temsirolimus HT29 Santa Cruz Biotechnology (Santa Cruz, CA, US) DMSO mTOR 10μM
C026 Everolimus HT29 Sigma DMSO mTOR 10μM
C027 PP242 HT29 Sigma DMSO mTOR 10μM
C028 Nimustine HT29 Sigma distilled water DNA alkylator 1mM
C029 SN-38 HT29 Yakult Co.Ltd., (Tokyo Japan) DMSO Topoisomerase I 1μM
C030 Camptothecin HT29 Sigma DMSO Topoisomerase I inhibitor 3μM
C031 Topotecan HT29 Sigma DMSO Topoisomerase I inhibitor 3μM
C032 Doxorubicin HT29 Sigma (St Louis, MO, US) DMSO DNA intercalator/TopoisomoeraseⅡ 1μM
C033 Etoposide HT29 Bristol-Myers Squibb DMSO Topoisomerase II inhibitor 30μM
C034 Mitoxantrone HT29 Sigma DMSO DNA intercalator/Topoisomerase II 3μM
C035 Pemetrexed HT29 Santa Cruz Biotechnology DMSO DNA/RNA synthesis 1μM
C036 Sorafenib HT29 Selleckchem DMSO VEGFR, PDGFR, Raf etc 10μM
C037 Sorafenib HT29 Selleckchem DMSO VEGFR, PDGFR, Raf etc 10μM
C038 Sunitinib HT29 Selleckchem DMSO, - VEGFR, PDGFR etc 10μM
C039 Sunitinib HT29 Selleckchem DMSO, - VEGFR, PDGFR etc 10μM
C040 Lapatinib HT29 Cell Signaling Technology DMSO EGFR/Her2 30μM
C041 Lapatinib HT29 Cell Signaling Technology DMSO EGFR/Her2 100μM
C042 Dasatinib HT29 Cell Signaling Technology (Danvers, MA, US) DMSO Bcr-Abl/Src 2nM
C043 Erlotinib HT29 Cell Signaling Technology DMSO EGFR 30μM
C044 Gefitinib HT29 Wako Pure Chemical Industries (Osaka, Japan) DMSO EGFR 10μM
C045 Gefitinib HT29 Wako Pure Chemical Industries (Osaka, Japan) DMSO EGFR 30μM
C046 Pazopanib HT29 Selleckchem? DMSO VEGFR, KIT, FGFR,PDGFR etc 30μM
C047 Vorinostat HT29 Cayman Chemical Company (Ann Arbor, MI, US) DMSO HDAC 10μM
C048 Bortezomib HT29 Millennium Pharmaceuticals Inc (Cambridge, MA, US) DMSO proteasome 100nM
C049 Geldanamycin HT29 Sigma DMSO Hsp90 30nM
C050 17-AAG HT29 Wako Pure Chemical Industries DMSO Hsp90 100nM
C051 Vincristine HT29 Eli Lilly (Indianapolis, IN, US distilled water tubulin 30nM
C052 Paclitaxel HT29 Bristo-Myers Squibb (New York, NY, US) DMSO tubulin 30nM
C053 Docetaxel HT29 Astra Zeneca, Inc (London, UK) DMSO tubulin 30nM
C054 5-FU HT29 Sigma DMSO Pyrimidine 100μM
C055 Mitomycin C HT29 Sigma 50%DMSO DNA alkylator 10μM
C056 Vorinostat HT29 Cayman Chemical Company (Ann Arbor, MI, US) DMSO HDAC 10μM
C057 Bortezomib HT29 Millennium Pharmaceuticals Inc (Cambridge, MA, US) DMSO proteasome 100nM
C058 Vorinostat HT29 Cayman Chemical Company (Ann Arbor, MI, US) DMSO HDAC 10μM
C059 Bortezomib HT29 Millennium Pharmaceuticals Inc (Cambridge, MA, US) DMSO proteasome 100nM
C060 Gemicitabine HT29 Eli Lilly Saline Pyrimidine 1μM
C061 Oxaliplatin HT29 Yakult Co.Ltd., DMSO DNA cross-linker 3μM
C062 Bleomycin HT29 Sigma distilled water DNA cleavage 30μg/ml
C063 Neocarzinostatin HT29 Sigma - DNA cleavage 3μg/ml
C064 Methotrexate HT29 Sigma DMSO DHFR 1μM
C065 6-Mercaptopurine HT29 Sigma DMSO Purine 100μM
C066 Temsirolimus HT29 Santa Cruz Biotechnology (Santa Cruz, CA, US) DMSO mTOR 10μM
C067 Everolimus HT29 Sigma DMSO mTOR 10μM
C068 PP242 HT29 Sigma DMSO mTOR 10μM
C069 Etoposide HT29 Bristol-Myers Squibb DMSO Topoisomerase II inhibitor 30μM
C070 Pemetrexed HT29 Santa Cruz Biotechnology DMSO DNA/RNA synthesis 1μM
C071 Amrubicin HT29 Santa Cruz Biotechnology DMSO Topoisomerase II inhibitor 10μM
C072 MLN-4924 HT29 Active Biochem (Hong Kong, Chin) DMSO Nedd8 activating enzyme 10μM
C073 Akt Inhibitor VIII HT29 Calbio Chem (San Diego, CA, US) DMSO Akt 1/2 10μM
C074 ATM/ATR kinase inhibitor HT29 Calbio Chem DMSO ATM,ATR 10μM
C075 Cdk4 inhibitor HT29 Calbio Chem DMSO CDK4 10μM
C076 SB218078 HT29 Calbio Chem DMSO Chk1 3μM
C077 Chk2 inhibitor II HT29 Calbio Chem DMSO Chk2 100μM
C078 GSK-3 inhibitor IX HT29 Calbio Chem DMSO GSK-3 10μM
C079 5-Aza-2'-deoxycytidine HT29 Wako Pure Chemical Industries DMSO DNA methyltransferase 100μM
C080 FH535 HT29 Calbio Chem DMSO beta-catenin/Tcf 30μM
C081 BI 2536 HT29 Selleckchem DMSO Polo-like kinase 10nM
C082 Aurora kinase inhibitor III HT29 Calbio Chem DMSO Aurora kinase 10μM
C083 NU6102 HT29 Calbio Chem DMSO cdk1/cyclinB 30μM
C084 TX-1918 HT29 Calbio Chem DMSO eukaryotic elongation factor-2 kinase (eEF2K) 10μM
C085 AG1024 HT29 Calbio Chem DMSO IGF1R 30μM
C086 U-0126 HT29 Wako Pure Chemical Industries DMSO MEK 30μM
C087 SU11274 HT29 Calbio Chem DMSO MET 30μM
C088 PDGFR inhibitor V HT29 Calbio Chem DMSO PDGFR 10μM
C089 PKR inhibitor HT29 Calbio Chem DMSO RNA-dependent protein kinase (PKR) 3μM
C090 Decitabine HT29 Selleckchem DMSO DNA methyltransferase 100μM
C091 Romidepsin HT29 Selleckchem DMSO HDAC 3nM
C092 Vandetanib HT29 Selleckchem DMSO VEGFR, EGFR etc 10μM
C093 Vemurafenib HT29 Selleckchem DMSO BRAF(V600E) 30μM
C094 Crizotinib HT29 Selleckchem DMSO ALK 10μM
C095 Ruxolitinib HT29 Selleckchem DMSO JAK 100μM
C096 Axitinib HT29 Selleckchem DMSO VEGFR, KIT, PDGFR etc 100μM
C097 Vismodegib HT29 Selleckchem DMSO SMO 100μM
C098 Carfilzomib HT29 Selleckchem DMSO proteasome 10nM
C099 Regorafenib HT29 Selleckchem DMSO VEGFR, KIT, RET, Raf etc 30μM
C100 Cabozantinib HT29 Selleckchem DMSO VEGFR, MET,Ret,KIT,Flt1/3/4 etc 30μM
C101 SN-38 SKOV3 Yakult Co.Ltd., (Tokyo Japan) DMSO Topoisomerase I 1μM
C102 Doxorubicin SKOV3 Sigma (St Louis, MO, US) DMSO DNA intercalator/Topoisomoerase II 1μM
C103 Lapatinib SKOV3 Cell Signaling Technology DMSO EGFR/Her2 30μM
C104 SN-38 K562 Yakult Co.Ltd., (Tokyo Japan) DMSO TopoisomeraseⅠ 1μM
C105 Doxorubicin K562 Sigma (St Louis, MO, US DMSO DNA intercalator/Topoisomoerase II 1μM
C106 Imatinib K562 Selleckchem (Houston, TX, US) DMSO Bcr-Abl/KIT 0.6μM
C107 Bosutinib K562 Selleckchem DMSO Bcr-Abl/Src 200nM
C108 Dasatinib K562 Cell Signaling Technology (Danvers, MA, US) DMSO Bcr-Abl/Src 2nM
C109 Nilotinib K562 Selleckchem DMSO Bcr-Abl 20nM
C110 Ponatinib K562 Selleckchem DMSO Bcr-Abl(T315I) 6nM
C111 SN-38 PC-9 Yakult Co.Ltd., (Tokyo Japan) DMSO TopoisomeraseⅠ 1μM
C112 Doxorubicin PC-9 Sigma (St Louis, MO, US DMSO DNA intercalator/Topoisomoerase II 1μM
C113 Erlotinib PC-9 Cell Signaling Technology DMSO EGFR 0.6μM
C114 Erlotinib PC-9 Cell Signaling Technology DMSO EGFR 30μM
C115 Gefitinib PC-9 Wako Pure Chemical Industries (Osaka, Japan) DMSO EGFR 0.6μM
C116 Gefitinib PC-9 Wako Pure Chemical Industries (Osaka, Japan) DMSO EGFR 30μM
C117 Alectinib/CH5424802 HT29 Selleckchem DMSO ALK 10μM
C118 Celecoxib HT29 Selleckchem DMSO COX2 100μM
C119 BKM120 HT29 Selleckchem DMSO PI3K 3μM
C120 BEZ235 HT29 Santa Cruz Biotechnology DMSO PI3K/mTOR 1μM
C121 Dabrafenib HT29 Selleckchem DMSO BRAF(V600E) 10μM
C122 Trametinib HT29 Selleckchem DMSO MEK 1μM
C123 Afatinib HT29 Selleckchem DMSO EGFR/Her2 30nM
C124 Afatinib PC-9 Selleckchem DMSO EGFR/Her2 30nM
C125 Trametinib PC-9 Selleckchem DMSO MEK 1μM
C126 Crizotinib H2228 Selleckchem DMSO ALK 10μM
C127 Alectinib/CH5424802 H2228 Selleckchem DMSO ALK 10μM
C128 SN38 H2228 Yakult Co.Ltd., DMSO TopoisomeraseⅠ 3μM
C129 Doxorubicin H2228 Sigma (St Louis, MO, US) DMSO DNA intercalator/Topoisomoerase II 1μM