Chem_id |
Compound |
Cell |
Manufacturer |
Solvent |
Target/mode of action |
Concentration for treatment |
C001 |
2-Deoxyglucose |
HT29 |
Sigma |
distilled water |
glycolysis |
10mM |
C002 |
Tunicamycin |
HT29 |
Nacalai Tesque (Kyoto, Japan) |
DMSO |
N-glycosylation |
3μg/ml |
C003 |
Thapsigargin |
HT29 |
Wako Pure Chemical Industries |
DMSO |
SERCA |
10nM |
C004 |
A23187 |
HT29 |
Wako Pure Chemical Industries |
DMSO |
Ca2+ ionophore |
3μM |
C005 |
Cisplatin |
HT29 |
Bristol-Myers Squibb |
DMSO |
DNA cross-linker |
30μM |
C006 |
Trichostatin A |
HT29 |
Wako Pure Chemical Industries |
DMSO |
HDAC |
300nM |
C007 |
Vorinostat |
HT29 |
Cayman Chemical Company (Ann Arbor, MI, US) |
DMSO |
HDAC |
10μM |
C008 |
Bortezomib |
HT29 |
Millennium Pharmaceuticals Inc (Cambridge, MA, US) |
DMSO |
proteasome |
100nM |
C009 |
MG-132 |
HT29 |
Peptide Institute (Osaka, Japan) |
DMSO |
proteasome |
1μM |
C010 |
Geldanamycin |
HT29 |
Sigma |
DMSO |
Hsp90 |
30nM |
C011 |
17-AAG |
HT29 |
Wako Pure Chemical Industries |
DMSO |
Hsp90 |
100nM |
C012 |
Vincristine |
HT29 |
Eli Lilly (Indianapolis, IN, US) |
distilled water |
tubulin |
30nM |
C013 |
Paclitaxel |
HT29 |
Bristo-Myers Squibb (New York, NY, US) |
DMSO |
tubulin |
30nM |
C014 |
Docetaxel |
HT29 |
Astra Zeneca, Inc (London, UK) |
DMSO |
tubulin |
30nM |
C015 |
5-FU |
HT29 |
Sigma |
DMSO |
Pyrimidine |
100μM |
C016 |
Gemicitabine |
HT29 |
Eli Lilly |
Saline |
Pyrimidine |
1μM |
C017 |
Melphalan |
HT29 |
Sigma |
75%DMSO |
DNA cross-linker |
100μM |
C018 |
Mitomycin C |
HT29 |
Sigma |
50%DMSO |
DNA alkylator |
10μM |
C019 |
Oxaliplatin |
HT29 |
Yakult Co.Ltd., |
DMSO |
DNA cross-linker |
3μM |
C020 |
Bleomycin |
HT29 |
Sigma |
distilled water |
DNA cleavage? |
30μg/ml |
C021 |
Actinomycin D |
HT29 |
Sigma |
DMSO |
DNA replication/RNA synthesis |
30nM |
C022 |
Neocarzinostatin |
HT29 |
Sigma |
- |
DNA cleavage? |
3μg/ml |
C023 |
Methotrexate |
HT29 |
Sigma |
DMSO |
DHFR |
1μM |
C024 |
6-Mercaptopurine |
HT29 |
Sigma |
DMSO |
Purine |
100μM |
C025 |
Temsirolimus |
HT29 |
Santa Cruz Biotechnology (Santa Cruz, CA, US) |
DMSO |
mTOR |
10μM |
C026 |
Everolimus |
HT29 |
Sigma |
DMSO |
mTOR |
10μM |
C027 |
PP242 |
HT29 |
Sigma |
DMSO |
mTOR |
10μM |
C028 |
Nimustine |
HT29 |
Sigma |
distilled water |
DNA alkylator |
1mM |
C029 |
SN-38 |
HT29 |
Yakult Co.Ltd., (Tokyo Japan) |
DMSO |
Topoisomerase I |
1μM |
C030 |
Camptothecin |
HT29 |
Sigma |
DMSO |
Topoisomerase I inhibitor |
3μM |
C031 |
Topotecan |
HT29 |
Sigma |
DMSO |
Topoisomerase I inhibitor |
3μM |
C032 |
Doxorubicin |
HT29 |
Sigma (St Louis, MO, US) |
DMSO |
DNA intercalator/TopoisomoeraseⅡ |
1μM |
C033 |
Etoposide |
HT29 |
Bristol-Myers Squibb |
DMSO |
Topoisomerase II inhibitor |
30μM |
C034 |
Mitoxantrone |
HT29 |
Sigma |
DMSO |
DNA intercalator/Topoisomerase II |
3μM |
C035 |
Pemetrexed |
HT29 |
Santa Cruz Biotechnology |
DMSO |
DNA/RNA synthesis |
1μM |
C036 |
Sorafenib |
HT29 |
Selleckchem |
DMSO |
VEGFR, PDGFR, Raf etc |
10μM |
C037 |
Sorafenib |
HT29 |
Selleckchem |
DMSO |
VEGFR, PDGFR, Raf etc |
10μM |
C038 |
Sunitinib |
HT29 |
Selleckchem |
DMSO, - |
VEGFR, PDGFR etc |
10μM |
C039 |
Sunitinib |
HT29 |
Selleckchem |
DMSO, - |
VEGFR, PDGFR etc |
10μM |
C040 |
Lapatinib |
HT29 |
Cell Signaling Technology |
DMSO |
EGFR/Her2 |
30μM |
C041 |
Lapatinib |
HT29 |
Cell Signaling Technology |
DMSO |
EGFR/Her2 |
100μM |
C042 |
Dasatinib |
HT29 |
Cell Signaling Technology (Danvers, MA, US) |
DMSO |
Bcr-Abl/Src |
2nM |
C043 |
Erlotinib |
HT29 |
Cell Signaling Technology |
DMSO |
EGFR |
30μM |
C044 |
Gefitinib |
HT29 |
Wako Pure Chemical Industries (Osaka, Japan) |
DMSO |
EGFR |
10μM |
C045 |
Gefitinib |
HT29 |
Wako Pure Chemical Industries (Osaka, Japan) |
DMSO |
EGFR |
30μM |
C046 |
Pazopanib |
HT29 |
Selleckchem? |
DMSO |
VEGFR, KIT, FGFR,PDGFR etc |
30μM |
C047 |
Vorinostat |
HT29 |
Cayman Chemical Company (Ann Arbor, MI, US) |
DMSO |
HDAC |
10μM |
C048 |
Bortezomib |
HT29 |
Millennium Pharmaceuticals Inc (Cambridge, MA, US) |
DMSO |
proteasome |
100nM |
C049 |
Geldanamycin |
HT29 |
Sigma |
DMSO |
Hsp90 |
30nM |
C050 |
17-AAG |
HT29 |
Wako Pure Chemical Industries |
DMSO |
Hsp90 |
100nM |
C051 |
Vincristine |
HT29 |
Eli Lilly (Indianapolis, IN, US |
distilled water |
tubulin |
30nM |
C052 |
Paclitaxel |
HT29 |
Bristo-Myers Squibb (New York, NY, US) |
DMSO |
tubulin |
30nM |
C053 |
Docetaxel |
HT29 |
Astra Zeneca, Inc (London, UK) |
DMSO |
tubulin |
30nM |
C054 |
5-FU |
HT29 |
Sigma |
DMSO |
Pyrimidine |
100μM |
C055 |
Mitomycin C |
HT29 |
Sigma |
50%DMSO |
DNA alkylator |
10μM |
C056 |
Vorinostat |
HT29 |
Cayman Chemical Company (Ann Arbor, MI, US) |
DMSO |
HDAC |
10μM |
C057 |
Bortezomib |
HT29 |
Millennium Pharmaceuticals Inc (Cambridge, MA, US) |
DMSO |
proteasome |
100nM |
C058 |
Vorinostat |
HT29 |
Cayman Chemical Company (Ann Arbor, MI, US) |
DMSO |
HDAC |
10μM |
C059 |
Bortezomib |
HT29 |
Millennium Pharmaceuticals Inc (Cambridge, MA, US) |
DMSO |
proteasome |
100nM |
C060 |
Gemicitabine |
HT29 |
Eli Lilly |
Saline |
Pyrimidine |
1μM |
C061 |
Oxaliplatin |
HT29 |
Yakult Co.Ltd., |
DMSO |
DNA cross-linker |
3μM |
C062 |
Bleomycin |
HT29 |
Sigma |
distilled water |
DNA cleavage |
30μg/ml |
C063 |
Neocarzinostatin |
HT29 |
Sigma |
- |
DNA cleavage |
3μg/ml |
C064 |
Methotrexate |
HT29 |
Sigma |
DMSO |
DHFR |
1μM |
C065 |
6-Mercaptopurine |
HT29 |
Sigma |
DMSO |
Purine |
100μM |
C066 |
Temsirolimus |
HT29 |
Santa Cruz Biotechnology (Santa Cruz, CA, US) |
DMSO |
mTOR |
10μM |
C067 |
Everolimus |
HT29 |
Sigma |
DMSO |
mTOR |
10μM |
C068 |
PP242 |
HT29 |
Sigma |
DMSO |
mTOR |
10μM |
C069 |
Etoposide |
HT29 |
Bristol-Myers Squibb |
DMSO |
Topoisomerase II inhibitor |
30μM |
C070 |
Pemetrexed |
HT29 |
Santa Cruz Biotechnology |
DMSO |
DNA/RNA synthesis |
1μM |
C071 |
Amrubicin |
HT29 |
Santa Cruz Biotechnology |
DMSO |
Topoisomerase II inhibitor |
10μM |
C072 |
MLN-4924 |
HT29 |
Active Biochem (Hong Kong, Chin) |
DMSO |
Nedd8 activating enzyme |
10μM |
C073 |
Akt Inhibitor VIII |
HT29 |
Calbio Chem (San Diego, CA, US) |
DMSO |
Akt 1/2 |
10μM |
C074 |
ATM/ATR kinase inhibitor |
HT29 |
Calbio Chem |
DMSO |
ATM,ATR |
10μM |
C075 |
Cdk4 inhibitor |
HT29 |
Calbio Chem |
DMSO |
CDK4 |
10μM |
C076 |
SB218078 |
HT29 |
Calbio Chem |
DMSO |
Chk1 |
3μM |
C077 |
Chk2 inhibitor II |
HT29 |
Calbio Chem |
DMSO |
Chk2 |
100μM |
C078 |
GSK-3 inhibitor IX |
HT29 |
Calbio Chem |
DMSO |
GSK-3 |
10μM |
C079 |
5-Aza-2'-deoxycytidine |
HT29 |
Wako Pure Chemical Industries |
DMSO |
DNA methyltransferase |
100μM |
C080 |
FH535 |
HT29 |
Calbio Chem |
DMSO |
beta-catenin/Tcf |
30μM |
C081 |
BI 2536 |
HT29 |
Selleckchem |
DMSO |
Polo-like kinase |
10nM |
C082 |
Aurora kinase inhibitor III |
HT29 |
Calbio Chem |
DMSO |
Aurora kinase |
10μM |
C083 |
NU6102 |
HT29 |
Calbio Chem |
DMSO |
cdk1/cyclinB |
30μM |
C084 |
TX-1918 |
HT29 |
Calbio Chem |
DMSO |
eukaryotic elongation factor-2 kinase (eEF2K) |
10μM |
C085 |
AG1024 |
HT29 |
Calbio Chem |
DMSO |
IGF1R |
30μM |
C086 |
U-0126 |
HT29 |
Wako Pure Chemical Industries |
DMSO |
MEK |
30μM |
C087 |
SU11274 |
HT29 |
Calbio Chem |
DMSO |
MET |
30μM |
C088 |
PDGFR inhibitor V |
HT29 |
Calbio Chem |
DMSO |
PDGFR |
10μM |
C089 |
PKR inhibitor |
HT29 |
Calbio Chem |
DMSO |
RNA-dependent protein kinase (PKR) |
3μM |
C090 |
Decitabine |
HT29 |
Selleckchem |
DMSO |
DNA methyltransferase |
100μM |
C091 |
Romidepsin |
HT29 |
Selleckchem |
DMSO |
HDAC |
3nM |
C092 |
Vandetanib |
HT29 |
Selleckchem |
DMSO |
VEGFR, EGFR etc |
10μM |
C093 |
Vemurafenib |
HT29 |
Selleckchem |
DMSO |
BRAF(V600E) |
30μM |
C094 |
Crizotinib |
HT29 |
Selleckchem |
DMSO |
ALK |
10μM |
C095 |
Ruxolitinib |
HT29 |
Selleckchem |
DMSO |
JAK |
100μM |
C096 |
Axitinib |
HT29 |
Selleckchem |
DMSO |
VEGFR, KIT, PDGFR etc |
100μM |
C097 |
Vismodegib |
HT29 |
Selleckchem |
DMSO |
SMO |
100μM |
C098 |
Carfilzomib |
HT29 |
Selleckchem |
DMSO |
proteasome |
10nM |
C099 |
Regorafenib |
HT29 |
Selleckchem |
DMSO |
VEGFR, KIT, RET, Raf etc |
30μM |
C100 |
Cabozantinib |
HT29 |
Selleckchem |
DMSO |
VEGFR, MET,Ret,KIT,Flt1/3/4 etc |
30μM |
C101 |
SN-38 |
SKOV3 |
Yakult Co.Ltd., (Tokyo Japan) |
DMSO |
Topoisomerase I |
1μM |
C102 |
Doxorubicin |
SKOV3 |
Sigma (St Louis, MO, US) |
DMSO |
DNA intercalator/Topoisomoerase II |
1μM |
C103 |
Lapatinib |
SKOV3 |
Cell Signaling Technology |
DMSO |
EGFR/Her2 |
30μM |
C104 |
SN-38 |
K562 |
Yakult Co.Ltd., (Tokyo Japan) |
DMSO |
TopoisomeraseⅠ |
1μM |
C105 |
Doxorubicin |
K562 |
Sigma (St Louis, MO, US |
DMSO |
DNA intercalator/Topoisomoerase II |
1μM |
C106 |
Imatinib |
K562 |
Selleckchem (Houston, TX, US) |
DMSO |
Bcr-Abl/KIT |
0.6μM |
C107 |
Bosutinib |
K562 |
Selleckchem |
DMSO |
Bcr-Abl/Src |
200nM |
C108 |
Dasatinib |
K562 |
Cell Signaling Technology (Danvers, MA, US) |
DMSO |
Bcr-Abl/Src |
2nM |
C109 |
Nilotinib |
K562 |
Selleckchem |
DMSO |
Bcr-Abl |
20nM |
C110 |
Ponatinib |
K562 |
Selleckchem |
DMSO |
Bcr-Abl(T315I) |
6nM |
C111 |
SN-38 |
PC-9 |
Yakult Co.Ltd., (Tokyo Japan) |
DMSO |
TopoisomeraseⅠ |
1μM |
C112 |
Doxorubicin |
PC-9 |
Sigma (St Louis, MO, US |
DMSO |
DNA intercalator/Topoisomoerase II |
1μM |
C113 |
Erlotinib |
PC-9 |
Cell Signaling Technology |
DMSO |
EGFR |
0.6μM |
C114 |
Erlotinib |
PC-9 |
Cell Signaling Technology |
DMSO |
EGFR |
30μM |
C115 |
Gefitinib |
PC-9 |
Wako Pure Chemical Industries (Osaka, Japan) |
DMSO |
EGFR |
0.6μM |
C116 |
Gefitinib |
PC-9 |
Wako Pure Chemical Industries (Osaka, Japan) |
DMSO |
EGFR |
30μM |
C117 |
Alectinib/CH5424802 |
HT29 |
Selleckchem |
DMSO |
ALK |
10μM |
C118 |
Celecoxib |
HT29 |
Selleckchem |
DMSO |
COX2 |
100μM |
C119 |
BKM120 |
HT29 |
Selleckchem |
DMSO |
PI3K |
3μM |
C120 |
BEZ235 |
HT29 |
Santa Cruz Biotechnology |
DMSO |
PI3K/mTOR |
1μM |
C121 |
Dabrafenib |
HT29 |
Selleckchem |
DMSO |
BRAF(V600E) |
10μM |
C122 |
Trametinib |
HT29 |
Selleckchem |
DMSO |
MEK |
1μM |
C123 |
Afatinib |
HT29 |
Selleckchem |
DMSO |
EGFR/Her2 |
30nM |
C124 |
Afatinib |
PC-9 |
Selleckchem |
DMSO |
EGFR/Her2 |
30nM |
C125 |
Trametinib |
PC-9 |
Selleckchem |
DMSO |
MEK |
1μM |
C126 |
Crizotinib |
H2228 |
Selleckchem |
DMSO |
ALK |
10μM |
C127 |
Alectinib/CH5424802 |
H2228 |
Selleckchem |
DMSO |
ALK |
10μM |
C128 |
SN38 |
H2228 |
Yakult Co.Ltd., |
DMSO |
TopoisomeraseⅠ |
3μM |
C129 |
Doxorubicin |
H2228 |
Sigma (St Louis, MO, US) |
DMSO |
DNA intercalator/Topoisomoerase II |
1μM |