Treatment Sample ID |
compound | Control Sample ID |
manufacturer | solvent | Target/mode of action | concentration |
GR001 | Cisplatin | CS1 | Bristol-Myers Squibb (New York, USA) | DMSO | DNA cross-linker | 30μM |
GR002 | Trichostatin A | CS1 | Wako Pure Chemical Industries (Osaka, Japan) | DMSO | HDAC | 300nM |
GR003 | Vorinostat | CS1 | Cayman Chemical Company (Ann Arbor, USA) | DMSO | HDAC | 10μM |
GR004 | Bortezomib | CS1 | Millennium Pharmaceuticals Inc (Cambridge, USA) | DMSO | proteasome | 100nM |
GR005 | MG-132 | CS1 | Peptide Institute (Osaka) | DMSO | proteasome | 1μM |
GR006 | Geldanamycin | CS1 | Sigma (St Louis, USA) | DMSO | Hsp90 | 30nM |
GR007 | 17-AAG | CS1 | Wako Pure Chemical Industries (Osaka) | DMSO | Hsp90 | 100nM |
GR008 | Vincristine | CS2 | Eli Lilly (Indianapolis, USA) | distilled water | Tubulin | 30nM |
GR009 | Paclitaxel | CS2 | Bristol-Myers Squibb (New York, USA) | DMSO | Tubulin | 30nM |
GR010 | Docetaxel | CS2 | Astra Zeneca, Inc (London, UK) | DMSO | Tubulin | 30nM |
GR011 | 5-FU | CS2 | Sigma (St Louis, USA) | DMSO | Pyrimidine | 100μM |
GR012 | Gemicitabine | CS2 | Eli Lilly (Indianapolis, USA) | Saline | Pyrimidine | 1μM |
GR013 | Melphalan | CS3 | Sigma (St Louis, USA) | 75%DMSO | DNA cross-linker | 100μM |
GR014 | Mitomycin C | CS3 | Sigma (St Louis, USA) | 50%DMSO | DNA alkylator | 10μM |
GR015 | Oxaliplatin | CS3 | Yakult Co. Ltd., (Tokyo, Japan) | DMSO | DNA cross-linker | 3μM |
GR016 | Bleomycin | CS3 | Sigma (St Louis, USA) | distilled water | DNA cleavage | 30μg/ml |
GR017 | Actinomycin D | CS3 | Sigma (St Louis, USA) | DMSO | RNA synthesis | 30nM |
GR018 | Neocarzinostatin | CS3 | Sigma (St Louis, USA) | - | DNA cleavage | 3μg/ml |
GR019 | Methotrexate | CS3 | Sigma (St Louis, USA) | DMSO | DHFR | 1μM |
GR020 | 6-Mercaptopurine | CS3 | Sigma (St Louis, USA) | DMSO | Purine | 100μM |
GR021 | Temsirolimus | CS3 | Santa Cruz Biotechnology (Santa Cruz, USA) | DMSO | mTOR | 10μM |
GR022 | Everolimus | CS3 | Sigma (St Louis, USA) | DMSO | mTOR | 10μM |
GR023 | PP242 | CS3 | Sigma (St Louis, USA) | DMSO | mTOR | 10μM |
GR024 | Nimustine | CS4 | Sigma (St Louis, USA) | distilled water | DNA alkylator | 1mM |
GR025 | SN38 (Irinotecan) | CS4 | Yakult Co. Ltd., (Tokyo, Japan) | DMSO | Topo I | 3μM |
GR026 | Camptothecin | CS4 | Sigma (St Louis, USA) | DMSO | Topo I | 3μM |
GR027 | Topotecan | CS4 | Sigma (St Louis, USA) | DMSO | Topo I | 3μM |
GR028 | Doxorubicin | CS4 | Sigma (St Louis, USA) | DMSO | DNA intercalator/Topo II | 3μM |
GR029 | Etoposide | CS4 | Bristol-Myers Squibb (New York, USA) | DMSO | Topo II | 30μM |
GR030 | Mitoxantrone | CS4 | Sigma (St Louis, USA) | DMSO | DNA intercalator/Topo II | 3μM |
GR031 | Pemetrexed | CS4 | Santa Cruz Biotechnology (Santa Cruz, USA) | DMSO | DNA/RNA synthesis | 1μM |
GR032 | 2-Deoxyglucose | CS1 | Sigma (St Louis, USA) | distilled water | ER stress (glycolysis) | 10mM |
GR033 | Tunicamycin | CS1 | Nacalai Tesque (Kyoto, Japan) | DMSO | ER stress (N-glycosylation) | 3μg/ml |
GR034 | Thapsigargin | CS1 | Wako Pure Chemical Industries (Osaka, Japan) | DMSO | ER stress (SERCA) | 10nM |
GR035 | A23187 | CS1 | Wako Pure Chemical Industries (Osaka, Japan) | DMSO | ER stress (Ca2+ ionophore) | 3μM |
GR036 | Vorinostat (16h) | CS5 | ||||
GR037 | Bortezomib (16h) | CS5 | ||||
GR038 | Vincristine (16h) | CS5 | ||||
GR039 | Paclitaxel (16h) | CS5 | ||||
GR040 | Docetaxel (16h) | CS5 | ||||
GR041 | 5-FU (16h) | CS5 | ||||
GR042 | Mitomycin C (16h) | CS5 | ||||
GR043 | Vorinostat | CS6 | ||||
GR044 | Bortezomib | CS6 | ||||
GR045 | Vorinostat (16h) | CS7 | ||||
GR046 | Bortezomib (16h) | CS7 | ||||
GR047 | Gemicitabine (16h) | CS8 | ||||
GR048 | Oxaliplatin (16h) | CS8 | ||||
GR049 | Bleomycin (16h) | CS8 | ||||
GR050 | Neocarzinostatin (16h) | CS8 | ||||
GR051 | Methotrexate (16h) | CS8 | ||||
GR052 | 6-Mercaptopurine (16h) | CS8 | ||||
GR053 | PP242 (16h) | CS8 | ||||
GR054 | Etoposide (16h) | CS8 | ||||
GR055 | Pemetrexed (16h) | CS8 |