Gene expression change database

Download page for up- or down-regulated gene list is here (CSV files for each compoud can be downloaded.)

The number of up- and down-regulated gene signatures for 35 anticancer compounds (55 treatment samples)
Treatment
Sample ID
compound up
x3 (x2)
down
x3 (x2)
Treatment
Sample ID
compound up
x3 (x2)
down
x3 (x2)
GR001 Cisplatin 19 (256) 52 (697) GR029 Etoposide 2 (41) 7 (133)
GR002 Trichostatin A 232 (1427) 181 (1238) GR030 Mitoxantrone 47 (312) 179 (1408)
GR003 Vorinostat 233 (1389) 173 (1245) GR031 Pemetrexed 2 (16) 5 (34)
GR004 Bortezomib 94 (494) 68 (659) GR032 2-Deoxyglucose 130 (586) 16 (439)
GR005 MG-132 63 (428) 51 (583) GR033 Tunicamycin 209 (768) 63 (673)
GR006 Geldanamycin 0 (29) 0 (32) GR034 Thapsigargin 69 (323) 3 (119)
GR007 17-AAG 7 (68) 0 (41) GR035 A23187 266 (986) 86 (931)
GR008 Vincristine 0 (45) 0 (6) GR036 Vorinostat (16h) 434 (2142) 478 (2057)
GR009 Paclitaxel 0 (41) 0 (9) GR037 Bortezomib (16h) 268 (1379) 299 (1882)
GR010 Docetaxel 1 (37) 0 (8) GR038 Vincristine (16h) 28 (293) 77 (335)
GR011 5-FU 3 (131) 14 (154) GR039 Paclitaxel (16h) 21 (263) 60 (281)
GR012 Gemicitabine 2 (26) 5 (49) GR040 Docetaxel (16h) 18 (221) 57 (270)
GR013 Melphalan 85 (716) 242 (1553) GR041 5-FU (16h) 26 (543) 39 (556)
GR014 Mitomycin C 3 (69) 9 (252) GR042 Mitomycin C (16h) 25 (404) 57 (605)
GR015 Oxaliplatin 0 (11) 9 (81) GR043 Vorinostat (16h) 297 (1543) 229 (1444)
GR016 Bleomycin 0 (6) 1 (5) GR044 Bortezomib (16h) 118 (596) 97 (904)
GR017 Actinomycin D 26 (294) 188 (1384) GR045 Vorinostat (16h) 462 (2266) 465 (2106)
GR018 Neocarzinostatin 0 (57) 2 (138) GR046 Bortezomib (16h) 307 (1551) 373 (1893)
GR019 Methotrexate 1 (28) 8 (62) GR047 Gemicitabine (16h) 15 (339) 8 (186)
GR020 6-Mercaptopurine 2 (38) 2 (52) GR048 Oxaliplatin (16h) 7 (167) 53 (410)
GR021 Temsirolimus 10 (132) 0 (24) GR049 Bleomycin (16h) 3 (23) 7 (29)
GR022 Everolimus 16 (162) 0 (13) GR050 Neocarzinostatin (16h) 13 (255) 9 (180)
GR023 PP242 98 (788) 37 (530) GR051 Methotrexate (16h) 67 (692) 53 (507)
GR024 Nimustine 7 (131) 13 (318) GR052 6-Mercaptopurine (16h) 35 (388) 9 (273)
GR025 SN38 (Irinotecan) 75 (602) 512 (2445) GR053 PP242 (16h) 192 (1206) 106 (924)
GR026 Camptothecin 102 (735) 809 (3151) GR054 Etoposide (16h) 33 (456) 31 (405)
GR027 Topotecan 28 (576) 190 (1268) GR055 Pemetrexed (16h) 24 (400) 8 (186)
GR028 Doxorubicin 49 (459) 184 (1323)